Formulation R&D

Preformulation studies

Preformulation is a part of a drug candidate selection process that utilizes biopharmaceutical principles to determine the physicochemical properties of a drug substance. Preformulation studies include solubility, stability, compatibility with common excipients, polymorph and salt form selections.

Formulation of poorly water soluble compounds via nanotechnology

We are experts in formulating poorly water soluble compounds using nanotechnology, as they are good candidates for nanosizing by media milling. The nanoparticles produced by wet-bead milling are usually not stable by themselves and appropriate stabilizers are needed to prevent the nanoparticles from agglomerating to form large particles.

Drug formulations containing nanoparticles often show improved bioavailability and better PK/PD relationships compared to conventional formulations. Nanoparticles can be formulated into liquid (oral suspensions, IV, and IM) as well as solid (capsules and tablets) dosage forms.

Formulation of unstable compounds using cyclodextrins

Compounds with poor stability in aqueous solution as well as poor compatibility with excipients can be formulated using cyclodextrins. Small molecules form inclusion complexes with these cyclodextrins and are then protected from hydrolytic reactions and reacting with other components.